Download 2011-2012 Basic and Clinical Science Course, Section 9: by Ramana S. Moorthy MD PDF

By Ramana S. Moorthy MD

Starts with an in-depth assessment of immunemedicated eye affliction, summarizing uncomplicated immunologic innovations, ocular immune responses and distinctive themes in ocular immunology. Discusses the scientific method of uveitis and experiences noninfectious (autoimmune) and infectious kinds of uveitis, with an accelerated part on viral uveitis and new fabric on infectious and noninfectious scleritis. improved detection of infectious brokers by means of immunologic and genetic equipment and new biologic therapeutics are specific. additionally covers endophthalmitis, masquerade syndromes, problems of uveitis and ocular elements of AIDS. encompasses a variety of new colour photographs. significant revision 2011-2012

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Additional info for 2011-2012 Basic and Clinical Science Course, Section 9: Intraocular Inflammation and Uveitis (Basic & Clinical Science Course)

Sample text

The term paratope refers to the epitope-specific binding site on the Fab (fragment. antigen-binding) portion of the antibody. In addition. antigenic proteins can be enzymatically digested into many different peptide fragments by APCs. some of which then serve as antigenic epitopes for T lymphocytes. Afferent lymphatic channels Also simply called lymphatics. afferent lymphatic channels are veinlike structures that drain extracellular fluid (ie. lymph) from a site into a regional node. Lymphatics serve 2 major purposes: to convey immune cells and to carry whole antigen from the site of inoculation to a lymph node.

The antigen is digested into peptide fragments and placed into the groove fo rmed by the a and p chains of the human leukocyte antigen IHLA) class II molecule . 3, The CD4 T-Iymphocyte receptor recognizes the fragmentclass II complex. 4, With the help of costimulatory molecules such as CD28-87 and cytokines. Figur. 2-3 the CD4 T lymphocyte becomes primed. or partially activated. (Illus tration by Barb Cousins. ) HLA complex and the T-lymphocyte receptor. When helper T lymphocytes specific for an anti gen become primed and partially ac tivated, they acquire new functional properties, including cell division, cytokine synth esis, and cell m embrane expressio n of accessory molecules such as cell-adhesio n molecules and costim ulatory molecules.

New York, N Y: WH Freeman; 2003. Male DK, Cooke A, Owen M, Trowsdale J, Champion B. Advanced Immunology. 3rd ed. 5t Louis, MO: Mosby; 1996. Antibody-Mediated Immune Effector Responses Structural and functional properties of antibody molecules Structural features of immunoglobulins Five major classes (M, G, A, E, and D) of immunoglobulin exist in 9 different subclasses, or isotypes (IgGI, IgG2, IgG3, IgG4, IgM, IgAI, IgA2, IgE, and IgD). The basic immunoglobulin structure is composed of 4 covalently bonded glycoprotein chains that form a monomer of approximately 150,000- 180,000 daltons (Fig 2-6).

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