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Extra resources for Anaphoric relations in English
In May GlaxoSmithKline (2006b) published a “Dear Healthcare Provider” announcement concerning Paxil-induced suicidality in depressed adults. The letter emphasized the supposedly slight increase in suicidality among young adults (through age 30) who take Paxil for a variety of conditions, including depression, panic attacks, anxiety, and obsessive—compulsive disorder. Far more important was the drug company’s description of a statistically signiﬁcant increase in suicidality in all ages of adults in the controlled clinical trials for major depression.
Paxil Is the Most Dangerous for Adults The FDA’s own analysis of all the adult controlled clinical trials found that Paxil was the most dangerous in regard to causing suicide attempts (Stone and Jones, 2006, p. 26). With the exception of Paxil, the individual antidepressants did not show a statistically signiﬁcant increase in adult suicidality. The signiﬁcant result came only after the data were pooled for all antidepressants. 02). Paxil stood out from the pack in terms of dangerousness despite GlaxoSmithKline’s efforts over many years to hide cases of Paxil-induced suicidality, to misidentify suicide attempts as emotional lability in their computerized coding system, and to manipulate the suicidality data to make it seem less menacing (chapter 14; Breggin 2006a—c).
Finally, in December 2006, the FDA held hearings concerning the potential addition of an adult suicide warning to all antidepressant labels. The data generated in older controlled clinical trials indicated that not only children but also young adults to age 24 were developing increased suicidal thoughts and actions when taking the newer antidepressants. The FDA’s panel ended up recommending a black-box warning about increased suicidality in the 18-to-24-year-old age group. The FDA’s committee was rife with conﬂicts of interest (Pringle, 2007).