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By Gaetano Santulli

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95] Xu Y, Yu Q. Angiopoietin-1, unlike angiopoietin-2, is incorporated into the extracellular matrix via its linker peptide region. J Biol Chem 2001;276:34990-8. [96] Carlson TR, Feng Y, Maisonpierre PC, Mrksich M, Morla AO. Direct cell adhesion to the angiopoietins mediated by integrins. J Biol Chem 2001;276:26516-25. [97] Gale NW, Yancopoulos GD. Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular development. Genes Dev 1999;13:1055-66.

Genes Dev 1999;13:295-306. [69] Oliver G, Detmar M. The rediscovery of the lymphatic system: old and new insights into the development and biological function of the lymphatic vasculature. Genes Dev 2002;16:773-83. [70] Folkman J. What is the evidence that tumors are angiogenesis dependent? J Natl Cancer Inst 1990;82:4-6. [71] Ferrara N. Role of vascular endothelial growth factor in the regulation of angiogenesis. Kidney Int 1999;56:794-814. [72] Carmeliet P. Mechanisms of angiogenesis and arteriogenesis.

118] Kerbel R, Folkman J. Clinical translation of angiogenesis inhibitors. Nat Rev Cancer 2002;2:727-39. [119] Man S, Bocci G, Francia G et al. Antitumor effects in mice of low-dose metronomic cyclophosphamide administered continuously through the drinking water. Cancer Res 2002;62:2731-5. [120] Brekken RA, Overholser JP, Stastny VA, Waltenberger J, Minna JD, Thorpe PE. Selective inhibition of vascular endothelial growth factor VEGF receptor 2 KDR/Flk-1 activity by a monoclonal anti-VEGF antibody blocks tumor growth in mice.

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